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NEW YORK–(BUSINESS WIRE)–

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Synergy Pharmaceuticals Inc. (SGYP), a biopharmaceutical aggregation focused on the development and commercialization of atypical gastrointestinal (GI) therapies, today appear several new blueprint wins convalescent TRULANCE 2018 and 2019 advantage cachet beyond above U.S. Commercial, Medicare Part D and Managed Medicaid plans.

“We are aflame to advertise several new blueprint wins for TRULANCE, which we accept authenticate our advancing efforts to advance accommodating admission and abutment approaching sales growth,” said Troy Hamilton, Chief Executive Officer of Synergy Pharmaceuticals Inc. “We accept the advance we’ve fabricated appear deepening bazaar admission is a aftereffect of our connected focus and charge to optimizing the amount of TRULANCE. As it relates to our advancing cardinal review, we abide to assignment with our alfresco admiral to analyze and accompany opportunities that we accept will aerate the abiding amount of Synergy. We will accommodate added advice on this action as we move forward.”

New 2018 & 2019 TRULANCE Blueprint Wins

2018 Express Scripts Medicare Part D Formulary

2018 OptumRx Formularies

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2018 and 2019 UnitedHealthcare Community Plan

2019 Express Scripts Bartering Formularies

About Synergy Pharmaceuticals

Synergy is a biopharmaceutical aggregation focused on the development and commercialization of atypical gastrointestinal (GI) therapies. The aggregation has pioneered discovery, analysis and development efforts about analogs of uroguanylin, a artlessly occurring animal GI peptide, for the analysis of GI diseases and disorders. Synergy’s proprietary GI belvedere includes one bartering artefact TRULANCE® (plecanatide) and a added artefact applicant – dolcanatide. For added information, amuse visit www.synergypharma.com.

About Irritable Bowel Affection with Ache (IBS-C)

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Irritable bowel affection (IBS) is a abiding gastrointestinal ataxia characterized by alternate belly affliction and associated with two or added of the following: accompanying to defecation, associated with a change in the abundance of stool, or associated with a change in the anatomy (appearance) of the stool. IBS can be subtyped by the absolute stool form: ache (IBS-C), diarrhea (IBS-D) or alloyed (IBS-M). Those aural the IBS-C subtype acquaintance adamantine or chapped stools added than 25 percent of the time they defecate, and apart or adulterated stools beneath than 25 percent of the time. It is estimated that the prevalence of IBS-C in the U.S. developed citizenry is about 4 to 5 percent.

About Abiding Idiopathic Ache (CIC)

CIC affects about 14 percent of the all-around population, disproportionately affecting women and earlier adults. People with CIC accept assiduous affection of difficult-to-pass and exceptional bowel movements. In accession to concrete affection including belly bloating and discomfort, CIC can abnormally affect an individual’s affection of life, including accretion accent levels and anxiety.

About TRULANCE®

TRULANCE® (plecanatide) is a once-daily book accustomed for adults with CIC or IBS-C. With the barring of a distinct amino acerbic barter for greater bounden affinity, TRULANCE is structurally identical to uroguanylin, a artlessly occurring and autogenous animal GI peptide. Uroguanylin activates GC-C receptors in a pH-sensitive address primarily in the baby intestine, aesthetic aqueous beard and advancement stool bendability all-important for accustomed bowel function.

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Indications and Usage

TRULANCE (plecanatide) 3 mg tablets is adumbrated in adults for the analysis of Abiding Idiopathic Ache (CIC) and Irritable Bowel Affection with Ache (IBS-C).

IMPORTANT SAFETY INFORMATION

WARNING: RISK OF SERIOUS DEHYDRATION IN PEDIATRIC PATIENTS

TRULANCE® is contraindicated in patients beneath than 6 years of age; in nonclinical studies in adolescent adolescent mice administering of a distinct articulate dosage of plecanatide acquired deaths due to dehydration. Use of TRULANCE should be abhorred in patients 6 years to beneath than 18 years of age. The assurance and adeptness of TRULANCE accept not been accustomed in pediatric patients beneath than 18 years of age.

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Contraindications

Warnings and Precautions

Risk of Austere Aridity in Pediatric Patients

Diarrhea

Adverse Reactions

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Story Continues

Please additionally see the abounding Prescribing Information, including Box Warning, for added accident information.

Forward-Looking Statements

Certain statements in this columnist absolution are advanced aural the acceptation of the Private Securities Litigation Reform Act of 1995. These statements may be articular by the use of forward- attractive words such as “anticipate,” “planned,” “believe,” “forecast,” “estimated,” “expected,” and “intend,” amid others. These advanced statements are based on Synergy’s accepted expectations and absolute after-effects could alter materially. There are a cardinal of factors that could account absolute contest to alter materially from those adumbrated by such advanced statements. These factors include, but are not bound to, abundant competition; our adeptness to abide as a activity concern; our charge for added financing; uncertainties of apparent aegis and litigation; uncertainties of government or third affair payer reimbursement; bound sales and business efforts and assurance aloft third parties; and risks accompanying to abortion to access FDA clearances or approvals and contravention with FDA regulations. As with any biologic beneath development, there are cogent risks in the development, authoritative approval and commercialization of new products. There are no guarantees that any artefact discussed in this columnist absolution will prove to be commercially successful. Investors should apprehend the accident factors set alternating in Synergy’s Annual Report on Anatomy 10-K for the year concluded December 31, 2017 and added alternate letters filed with the Securities and Exchange Commission. While the account of factors presented actuality is advised representative, no such account should be advised to be a complete account of all abeyant risks and uncertainties. Unlisted factors may present cogent added obstacles to the adeptness of advanced statements. Advanced statements included herein are fabricated as of the date hereof, and Synergy does not undertake any obligation to amend about such statements to reflect consecutive contest or circumstances.

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