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Biomarin Biologic Inc  (NASDAQ:BMRN)Q3 2018 Earnings Appointment CallOct. 25, 2018, 4:30 p.m. ET

Operator

Welcome to the BioMarin Third division 2018 Banking After-effects Appointment Call. Hosting the appointment alarm today from BioMarin is Traci McCarty, Vice President of Investor Relations. Amuse go ahead, Tracy.

Traci McCarty — Vice President of Investor Relations

Thank you, Alexis. To admonish you, today’s alarm is non-confidential and contains avant-garde statements about the business affairs of BioMarin’s Pharmaceutical; including expectations apropos BioMarin’s banking performance, bartering accessories and abeyant aing accessories in altered areas of ameliorative analysis and development. After-effects may alter materially depending on the advance of BioMarin’s artefact programs, accomplishments of authoritative authorities, availability of capital, aing accomplishments in the biologic bazaar and developments by competitors, and those factors abundant in BioMarin’s filings with the SEC such as 10-Q, 10-K and 8-K reports.

On the alarm today from BioMarin administration are J.J. Bienaime, Chairman and Chief Executive Officer; Hank Fuchs, President, Common Analysis & Development; and Dan Spiegelman, EVP, Chief Banking Officer; Jeff Ajer, EVP, Chief Bartering Officer; and Robert Baffi, EVP of Technical Operations.

Now, I’d like to about-face the alarm over to BioMarin’s Chairman and CEO, J.J. Bienaime.

Jean-Jacques Bienaime — Chairman and Chief Executive Officer

Thank you, Traci. Acceptable afternoon, and accede you for aing us on today’s call. The aboriginal three abode of 2018 has been acutely advantageous and accept positioned us for added top band results, for the key abstracts after-effects for abeyant authoritative filings and a new IND in 2019. So our bartering aggregation has delivered almanac acquirement in this quarter, with the accession of Palynziq or Palynziq, we apprehend to abide to backbone $392 actor in this third division and $1.14 billion in the aboriginal three abode of the year, our both almanac top band results. And we abide on clue for about $1.5 billion in full-year revenues this year and $2 billion in 2020.

Starting with US Palynziq barrage in July afterwards approval in May. The antecedent barrage during the third division went acutely able-bodied and we had 124 reimbursed bartering Palynziq patients at the end of the quarter. We apprehend to add new appearance in Q4 and aloft as PKU Clinics Drive accommodating referrals and starts at a accident phase, and we apprehend amid 250 and 300 developed PKU patients to be on reimbursed bartering Palynziq’s by year end. We are absolute amuse with the akin of absorption in Palynziq, aback approval in May and Jeff will airing you and us through added added detail in a moment.

For Palynziq alfresco of US, we apprehend a CHMP Assessment on our business allotment appliance in Europe in the aboriginal bisected of 2019. And if that assessment is positive, we apprehend SEC Commission action followed by the abeyant barrage of Palynziq in the EU in the added bisected of 2019. As we attending avant-garde the aing important drivers of growth, our late-stage products, Val ox for Hemophilia A and Vosoritide for achondroplasia are both tracking to plan in their Appearance 3 studies. After-effects from the abounding 52-week abstracts readouts of vosoritide is targeted in the added bisected of 2019. And Valrox 6e13 dosage in mid 2020, with abeyant authoritative filings for approval to follow. Moreover, we’re aflame by the anticipation of potentially filing for accelerated approval of valrox in the added bisected of aing year.

Looking aloft our accomplished late-stage analytic projects, we plan to advantage our valrox acquaintance to advance added gene analysis products. The aing one actuality phenylketonuria readout. We plan to accommodate a abysmal dive into our gene therapies capabilities, our all-encompassing pre-clinical abstracts on our PKU gene analysis accessories and how we’re cerebration about the development mural with this belvedere at our accessible R&D Day in New York on November 7th. And we attending avant-garde to seeing you there. Afresh conclusion, we are absolute admiring with our ability to-date in 2018, we are aflame about our affairs for 2019 and beyond.

I will now about-face it over to Jeff, who will allotment accommodation of the US Palynziq launch, as able-bodied as amend on our added bartering products. Jeff?

Jeffrey Robert Ajer — Executive Vice President and Chief Bartering Officer

Thank you, J.J. Due to some inquiries accustomed from a few of you this morning, I’d like to accede the President’s accent today on proposed Medicare and biologic appraisement plans. Accustomed the all-around and avant-garde ambit of our business, we about advance a bound appraisement aisle aloft our bartering products. To admonish you, acquirement from allotment — Medicare Allotment B is beneath than 1% of our all-around book of business. We will abide to adviser anxiously abeyant changes and action that ability appulse BioMarin, but it is too aboriginal to say added until added accommodation are available.

Moving now to the US barrage of Palynziq and afresh do a airing through third division after-effects for our abject business. With over 11,000 developed PKU patients in US one-third of whom are actively actuality advised in the PKU clinic, Palynziq represents the better US accommodating citizenry of all our accustomed products. We alarm that abandoned 12% of all developed PKU patients in the US are actuality advised with Kuvan, so we accept a amazing befalling ahead, during this barrage period. We are focused on a cardinal of key metrics that are advance indicators of aing acquirement growth. The afterward were all abstinent as of the end of the third quarter; aboriginal there were 124 patients accepting reimbursed bartering analysis with Palynziq. Of these 81 are from the analytic studies and 43 were aforetime aboveboard to palynziq treatment.

In addition, at division end there were an added 68 aboveboard patients enrolled in our attenuate affiliation system, who accept alive all allotment forms afresh assigned Palynziq, afresh REMS accept and are now cat-and-mouse for their aboriginal bang to be shipped. By year-end, we apprehend amid 250 and 300 developed PKU patients to be on reimbursed bartering Palynziq. Second, at the end of the third division this (inaudible) clinics had one or added alive Palynziq patient. In addition, there were a absolute of 76 clinics that had at atomic one healthcare provider REMS certified. This is a key indicator of absorbed to appoint Palynziq and is commutual to our cogent efforts to in-service dispensary and accommodate apprenticeship on the use of Palynziq.

An auspicious ascertainment in the division for the PKU allotment was the action that developed Kuvan patients accept apparent for analysis with Palynziq. A allusive cardinal of developed Kuvan patients still seek to optimize our outcomes with greater fee ascendancy aback it’s been unachievable in the accomplished with Kuvan alone. To-date about 40% of aboveboard patients enrollments accept constituted alive Kuvan patients. Abiding and in the ambience of accepted accident of exclusivity for Kuvan in two years, this is a absolute absolute dynamic.

An important appliance for compassionate the Palynziq bazaar is the time it takes from that aboriginal bang to alive allusive revenue. To abridge in the aboriginal weeks, and in some cases months, aback a accommodating is alive through the consecration and titration appearance of treatment, their acquirement accession is fractional, about 10% to 20% of aliment revenue. Already circadian dosing has been achieved, added allusive acquirement contributions accept about 70% of our accepted bartering akin of $192,000 per accommodating per year will be recognized.

Once patients are on their aliment dose, d bisected are on 20 milligrams and bisected are on 40 milligrams daily, we still action net acquirement per accommodating at the $192,000 per accommodating per year of level. Accustomed the advancing about-face of analytic balloon patients to antithesis bartering patients and the predicted bashful acquirement accession during the antecedent months of Palynziq analysis for aboveboard patients. We believes Palynziq full-year acquirement in 2018 will be amid $10 actor and $14 million.

In summary, we are absolute admiring with the US Palynziq barrage and the advance fabricated the alteration analytic balloon patients to antithesis bartering product. Palynziq has been able-bodied accustomed by PKU association and we accept this is abandoned the alpha of accession acknowledged abiding contributor to our advance story.

Now axis to our added bartering products, which collection about 20% advance year-to-date, compared to aftermost year. Starting with Vimizim, which benefited from a ample Brazilian Ministry of Bloom adjustment in the quarter, able net artefact acquirement advance of 37% in the division and 23% year-to-date, compared to the aforementioned periods aftermost year, resulted in almanac year-to-date acquirement for the brand. We abide to acquaintance asperous acclimation patterns from assertive markets, which has the appulse of asperous anniversary acquirement pattern. As always, we animate you to accredit to the anniversary acquirement advice for both Vimizim and Naglazyme, which we reaffirm. Agnate bazaar dynamics were in comedy for Naglazyme in the third division and year-to-date with net artefact acquirement accretion 43% and 13% respectively, compared to the aforementioned aeon aftermost year.

Moving now to Brineura for the analysis of CLN2, which is aloof in its aboriginal fourth abounding division of bartering sales aback actuality accustomed in the US and EU mid-2017. In the third division of 2018, we abide to add new bartering patients constant in net acquirement of $9.9 million. We are authoritative advance adjoin our accompanying goals of anecdotic new patients from our ache acquaintance and analytic screening programs and civic agreement approvals. We are optimistic of apathetic but abiding advance of Brineura action forward, and apprehend that it will advance into a added absolute acquirement contributor.

In closing, the bartering aggregation delivered able net artefact revenues in the third division of 29% and 23% year-to-date. The barrage of Palynziq, our seven bartering accessories is aloft our expectations in agreement of accommodating and analyst interest. And we are confident, we are laying the background for a cogent acquirement contributor in the advancing quarters.

Now I’d like to about-face the alarm over to Dan to accommodate added accommodation on the banking after-effects in the third quarter. Dan?

Daniel Spiegelman — Executive Vice President and Chief Banking Officer

Thank you, Jeff. Beforehand today, we issued a columnist absolution summarizing our banking after-effects for the third quarter, and I accredit you to that absolution for abounding detail. Starting with topline results, as J.J and Jeff mentioned, we are admiring to abode the absolute revenues for the aboriginal three abode of 2018 were a almanac $1.14 billion, an admission of 19% year-over-year, apprenticed by able contributions from all of our marketed products. Adorable aloft 2018 and befitting with what we accept said previously, we apprehend topline advance over the aing brace of years to be about 15%, appropriately 2020 absolute acquirement should be about $2 billion from our accepted products, and we apprehend to clue against that acquirement allotment advance ambition until the accession from Vosoritide and Valrox faces aloft that level, hopefully at the alpha of aing decade.

Moving to operating expenses, R&D costs added to $161.4 actor in the third division of 2018, and $520.9 actor year-to-date 2018, compared to $154.1 actor and $442.1 actor in those corresponding periods of 2017. The year-to-date added in R&D is primarily due to added Valrox assembly and analytic balloon costs in abutment of advancing Appearance 3 program. Vosoritide analytic costs as the Appearance 3 arch against abounding acceptance in October. Tralesinidase aforetime referred to BMN 250, which reflects — that was still accessible we alarm assembly expenses.

Looking avant-garde to Q4, R&D costs should abide to aggrandize about to Q3 constant with the advance of our aloft analytic program, while absolute aural above-mentioned advice for the full-year. SG&A costs added to $148.6 actor in the third division of 2018 and $440.2 actor year-to-date, compared to $130.5 actor and $394.1 actor for the corresponding periods of 2017. The admission was primarily due to added sales and business costs associated with Kuvan, Brineura and Palynziq bartering efforts.

The year-to-date increases were primarily apprenticed by Palynziq and Brineura artefact barrage campaigns, and basic Valrox commercialization efforts. SG&A costs for the antithesis of the year and inter aboriginal aing year will admission hardly over above-mentioned division is apprenticed by the US Palynziq launch, a abeyant EU launch. Admitting these costs are accepted to abide aural the full-year advice for 2018.

Turning to basal band results, GAAP net accident in the third division 2018 was about flat, compared to the aforementioned aeon aftermost year at $12.6 actor in 2018, compared to $12.5 actor in the third division of 2017. Year-to-date, GAAP net accident in 2018 added hardly to $73.6 million, compared to $65.7 actor in 2017. As you know, we additionally admeasurement our achievement on a non-GAAP basis, which is based on EBITDA and excludes interest, taxes, abrasion and amortization. And additionally excludes banal compensation, accidental appliance and assertive added defined items.

In Q3, 2018 and for the fourth afterwards quarter, we recorded non-GAAP income, which added to $60.7 actor in 2018, compared to $7.8 actor in the third division of 2017. Adorable avant-garde to the fourth division of 2018, due to cancellation in Q3 of a ample Brazil MOH adjustment for both Naglazyme and Vimizim, we apprehend the Q4 revenues will be lower than Q3 revenues admitting still aural full-year guidance.

In addition, as acclaimed above, R&D and SG&A costs will additionally admission in Q4, but additionally still aural abounding year guidance. In absolute our GAAP and non-GAAP advice charcoal unchanged. In agreement of cash, banknote equivalents and investments as of September 30th, 2018, we had $1.7 billion, as compared to $1.8 billion at the end of 2017. In October of this year we activated about $375 actor to accord the arch on the convertible agenda that matured. With this conversion, we additionally issued 190,220 shares of our accepted banal and additionally accustomed fast 95,127 shares from CashCall counterparties. These shares accept afterwards been retired.

In closing, BioMarin delivered a able division and year-to-date after-effects in 2018 with able-bodied contributions from Vimizim and Naglazyme, abiding Kuvan net artefact revenues, ascendancy of operating costs and our connected advance against accretion non-GAAP advantage for the abounding year 2018, compared to 2017.

Now, I would like to about-face the alarm over to Hank.

Henry Fuchs — President, Common Analysis & Development

Thanks, Dan. Aback J.J. has already provided an overview of development and authoritative accomplishments so far this year, and because we accept R&D Day in November 7th, area we will accommodate abounding new updates. I’ll aloof booty a minute or two to draft on a few items. For Palynziq Europe, the business allotment appliance is beneath analysis and tracking the abrupt with CHMP accommodation accepted in the aboriginal bisected of 2019. Accustomed the action we’re seeing for Palynziq in US, we’re optimistic that the affecting Phe blurred accustomed in our analytic studies will construe able-bodied into appeal in ex-US regions.

Briefly on Valrox, we accept the contempo abstract FDA advice for the development of gene analysis accessories are absolute admiring of our Valrox abstraction architecture and approval pathways. The advocacy for Bureau VIII action in accustomed ambit to book with the FDA for an accelerated approval, raises the bar for after-effects beneath that ambit and gives us an important advancing advantage. Contempo discussions with Bloom Authorities increases our aplomb and our affairs to potentially accelerate registration. In accession to adjustment able-bodied with US Bloom Authorities, we are absolute encouraged by our advancing conversations and development planning with European Bloom Authorities.

And assuredly to admonish you of what to apprehend in our accessible R&D Day in November 7th, in New York, we attending avant-garde to a cardinal of agitative updates from the Analysis Group. In accession to analysis all the development products, we akin to accommodate key updates, including 42 months with Vosoritide of accouchement with Achondroplasia, as able-bodied as all-encompassing preclinical abstracts for our PKU Gene Analysis product. Accustomed the appliance of contempo key authoritative advances, we’re aflame to accept one of our accomplished colleagues from authoritative action in accommodating engagement, allotment insights into how BioMarin leverages action approaches to get accessories and amusement attenuate diseases approved.

And finally, our Chief Accurate Officer, Lon Cardon, will allotment his angle on the aing BioMarin’s activity and how he thinks about leveraging accurate addition and genomics. To accomplish our aing date of advance and beyond. It should be an absorbing and advisory event, so amuse try to appear in actuality or affability in via the webcast. As consistently accede you for your connected abutment and I’ll now accessible the alarm to your questions.

Operator

(Operator Instructions) And our aboriginal catechism is from Joseph Schwartz with Leerink Partners.

Joseph Schwartz — Leerink Partners — Analyst

Alright, great, acknowledgment absolute much. So I apperceive you don’t accept abundant medicare acknowledgment with your accepted products, but accustomed HHS’ new all-embracing advertence appraisement proposal, and how that could appulse aback to backup analysis in hemophilia? I was wondering, if you anticipate this could appulse your appraisement action for Valrox by extension, aback there could be lower abeyant bulk annual associated with your gene analysis to save the bloom adjustment spending on bureau backup therapy?

Jean-Jacques Bienaime — Chairman and Chief Executive Officer

Yes, I mean, I’ll alpha and aloof accord these comments. But and as you know, we accept the bulk fluctuate, acutely Valrox, because it is not accustomed yet. So we accept bulk in the US, it was priced in Europe. So, acutely this was — this will be an important consideration, if absolutely this does happen, but I anticipate we accept time and adaptability to appear up with the best appraisement action on both abandon of the Atlantic here. If absolutely this becomes a regulation, because there are lot of accommodation actuality that charge to be covered, and also, you know, abounding of you are already accepting a lot of discounts in the US. So I don’t know, if this is action to accomplish a huge aberration for us and aloof can accord you added details, but our boilerplate European bulk that compared the US government bulk is not that altered from our accepted products.

Jeffrey Robert Ajer — Executive Vice President and Chief Bartering Officer

Yes, acknowledgment J.J. not abundant to add to that I anticipate we’ve got affluence of time to be alive out the accommodation and as it relates to appraisement and agreement for gene analysis and added avant-garde accessories there maybe developments aural CMS that would facilitate our agreement models accredit you to agnate Obama’s contempo animadversion on the subject.

Joseph Schwartz — Leerink Partners — Analyst

Okay, great. That’s helpful, thanks. And afresh in your contempo abstracts adapted SSIEM, it attending like some patients on BMN 250 stabilized, but it wasn’t like Brineura, area all patients did I think. So do you anticipate that there’s any adventitious that you can get BMN 250 to bazaar on the absolute data? What do you anticipate is the best acceptable authoritative aisle for BMN 250, and aback do you apprehend to get accuracy from regulators?

Jean-Jacques Bienaime — Chairman and Chief Executive Officer

Hi, Joe. So the tralesinidase abstracts was presented at SSIEM accustomed affecting reductions in heparan sulfate levels and academician fluid, normalization of alarmist admeasurement in patients who accept hepatomegaly and stabilization in the development allocation and commodity like 5 out of 7 patients. DQ is a boxy endpoint, and I anticipate partly in acceptance of the claiming of documenting advance in acknowledgment in these kinds of diseases, the FDA issued a abstract advice certificate on the development of therapies for boring accelerating diseases, which we anticipate comes appealing aing to blockage all the boxes for Tralesinidase. So the aing footfall for us would be to accept a chat with Food and Biologic Administration about how those guidance, certificate accumulation and whether that presents an befalling to accomplishment authoritative pass. Suffice to say, we accept a fair bulk on our bowl adapted now, so I don’t appetite to accomplish to a accurate time anatomy about which to abode aback to you on that conversation.

Joseph Schwartz — Leerink Partners — Analyst

Okay, great, that’s cool helpful. Acknowledgment for demography my questions.

Operator

And your aing catechism is from Salveen Richter with Goldman Sachs.

Salveen Richter — Goldman Sachs — Analyst

Thanks for demography my question. And so with absorption to Valrox, it looks like you’re advancing the accelerated approval pathway, and afar from the abstracts from the Appearance 3 abstraction there do accept to be added factors that will comedy a role in your accommodation on this admission and so I was aloof apprehensive aback it comes to the appraisal and the alterity amid the chromogenic and the one date assay, can you advice us accept why there appears to be a alterity there, and the assignment that you accept to do about that for the filing or in adjustment to accompany a filing?

And afresh secondly, with absorption to the connected abstracts set from the advancing Appearance 2 abstraction and that contour actuality attacked — intact. Are you still assured stabilization there based on absolute circulating against non-circulating at the SUMO DNA. Aloof apprehensive if that apriorism is still complete in your mind?

Jeffrey Robert Ajer — Executive Vice President and Chief Bartering Officer

Yes. Hi, Salveen. So the affair of the appraisal alterity that was aloft in the advice certificate is to some admeasurement it is added of a accepted abnormality in branch accessories in that. These kinds of discrepancies accept been empiric for added products. And with the FDA wants to accomplish abiding is that there is no abeyant for under-dosing or overdosing, for that bulk of, we’re aggravating to alter some accessories on the base of a afield interpreted appraisal results.

And so they’ve asked the sponsors of gene analysis accessories to attending into that to the admeasurement that ability acquaint their decisions. And area they’re advancing from, in the ambience of gene analysis is that the transgene accessories may be biologically altered than the — were accepted and bureau accessories with which the FDA has a lot added familiarity. So to the point of establishing a Bureau VIII level, which is analytic acceptable to represent a analytic annual of advance reduction. The bureau has asked for two pieces of advice either bound or present data, which announce why you accept that the branch levels that you’re celebratory are analytic likely, and the FDA went on added to say that the abandoned bulk of Bureau VIII that they would accede for accelerated approval beneath these kinds of — in this ambience with the Bureau VIII levels that accomplished the accustomed range. So I anticipate that’s the — array of authoritative ambience for why this is an important catechism and how they operationalize it in agreement of their advice document.

And for the added allotment of your question, the added we attending at the abstract on assiduous forms of DNA in vivo in animals, we accept accustomed the transgene, the added assertive we are that the clearing phenomena is real, reliable, reproducible and analytic acceptable to administer to BMN 270 and of advance out in the, let’s alarm it at the ancient (ph) years afterwards gene alteration that we will beam clinically accordant and assiduous expression. Proof is acutely in the putting and we attending avant-garde to accouterment you an amend on area things angle in the average of aing year.

Jean-Jacques Bienaime — Chairman and Chief Executive Officer

And additionally I think, we can awning this, the mid-year to ambit or conversion. We action to awning in detail at R&D Day. And additionally based on some alternation with — had with authoritative authorities, we don’t accept that, we don’t accept that this, I’d say discrepancies, there will be a cogent for us.

Salveen Richter — Goldman Sachs — Analyst

Thank you.

Operator

(Operator Instructions) Accede you. And your aing catechism comes from Chris Raymond with Piper Jaffray.

Chris Raymond — Piper Jaffray — Analyst

Hi, acknowledgment for demography the question. So maybe aloof on Palynziq, you guys now bristles months in the launching, I apperceive it’s still affectionate of aboriginal days, but with the 43 analysis aboveboard patients you’ve gotten through arguably a adapted cardinal of these association accept gotten into that array of analytical eight weeks or so timeframe, I think, Hen could you describe, as the array of aeon aback you ability alive the better adventitious for anaphylaxis. Can you maybe alarm it, are you alive into annihilation abrupt during that time anatomy for some of those folks, you’re apropos along. And accept you apparent any discontinuations and maybe alarm what some of those attending like, and afresh maybe a allotment due to this question, any Kuvan patients are allotment of that 43. Accede you.

Jeffrey Robert Ajer — Executive Vice President and Chief Bartering Officer

So, and this is Jeff, abundant questions. Chris, let me see, if I can awning them. The aboriginal affair to agenda is, those numbers that we were commendation were as of the end of September and so we’ve got — action on accession ages of applied acquaintance with the launch. The all-inclusive majority of reactions that accept been reported, adverse contest or bang armpit reactions, which were absolutely accepted for Palynziq. We haven’t apparent added types of adverse contest reported, arthralgia or anaphylaxis, but to-date the admonition on that is because of the time it has taken to get new patients through the case administration agreement and alpha process, we don’t absolutely accept absolute abounding patients that accept gotten up to that circadian dosing with 20 milligrams and beyond, which is the point at which we would apprehend to alpha seeing added austere adverse contest aloft aloof the bang armpit reactions. So I anticipate ability be a acceptable catechism to ask, for three months from now.

In agreement of Kuvan patients aing 40% of our aboveboard accommodating acceptance accept been alive Kuvan patients, so there is a — fair bulk of alive switching action on which we anticipate is the absolutely absolute affair for the PKU franchise, all-embracing to get those patients, developed patients on the Palynziq and on to a aliment dosing able-bodied avant-garde of accident of exclusivity.

Jean-Jacques Bienaime — Chairman and Chief Executive Officer

There was a catechism on (inaudible) discontinuation.

Jeffrey Robert Ajer — Executive Vice President and Chief Bartering Officer

Discontinuation. So far we haven’t apparent any discontinuations from aboveboard patients, but again, we’re aloof accepting started with patients in that abridgement and titration phase.

Chris Raymond — Piper Jaffray — Analyst

Okay. Accede you absolute much.

Operator

And your aing catechism comes from Cory Kasimov with JPMorgan.

Carmen Augustine — JPMorgan — Analyst

Hi, it is Carmen on for Cory. Acknowledgment for demography our question. So your advice for Palynziq for full-year ’18, you mentioned you’re assured 250 to 300 bartering patients on drug, which implies if I am counting this correctly, accession 50 or so new accommodating starts at the low end of the guidance. And so that’s affectionate of inline with what you saw in the aboriginal division of launch. I’m apprehensive how we’re cerebration about that these new accommodating starts, as we get into 2019, compared to this? And what you anticipate will catalize affectionate of an uptick in new accommodating starts. Thanks.

Jeffrey Robert Ajer — Executive Vice President and Chief Bartering Officer

Hi. So let’s see, let’s get aback to those numbers. We appear that (Multiple Speakers) d that the antithesis of the analytic patients are the aboriginal ones in and that’s about 17 and accordingly accession 50 would get you to 250 at the everyman end of our guidance. So I anticipate that’s what you said.

Traci McCarty — Vice President of Investor Relations

Carmen, is that what you’re — you’ve asked for?

Carmen Augustine — JPMorgan — Analyst

Yes, yeah, that’s how I affected it.

Jean-Jacques Bienaime — Chairman and Chief Executive Officer

As your catechism is what are we adorable for uptick in that amount of new patients action avant-garde into aing year.

Jeffrey Robert Ajer — Executive Vice President and Chief Bartering Officer

Yeah, so it’s been at the amount of new accommodating acceptance has been acrimonious up throughout the third quarter, and we would apprehend that to abide as added of our ambition clinics become active, we’ll alarm this — we appear the 50 clinics are now active, we’ll alarm that it launch, we said that our Bank 1 clinics 32 of them that are advancing out of the analytic trial, annual for about 50% of developed patients, an added 30 clinics are bank 2 clinics that annual for 35% of developed patients. So if added clinics become alive the amount of acceptance should pickup, additionally what we’ve adventures a lot of the analytic balloon sites focus their antecedent efforts as they should accept in the third division in transitioning their analytic balloon patients. And with best of those patients now on commercially labeled drug, if not absolutely reimbursed biologic that should facilitate those clinics alpha enrolling new patients.

Carmen Augustine — JPMorgan — Analyst

Okay.

Operator

And your aing catechism comes from Robyn Karnauskas with Citi.

Kripa Devarakonda — Citi — Analyst

Hi, guys, this is Kripa on for Robyn. Accede you so abundant for demography my question. Accustomed that the absorption that you adumbrated in Kuvan patients to get assimilate Palynziq? How should we anticipate in agreement of about-face of switching of Kuvan patients to Palynziq in the long-term? Is there a allotment of patients that you apprehend to catechumen or do you anticipate majority or all of them will catechumen is there any blush you can accommodate for us. Accede you.

Jeffrey Robert Ajer — Executive Vice President and Chief Bartering Officer

We’ve declared that it’s an absolute cold of ours to accept as many, Kuvan developed patients adapted to Palynziq analysis as possible. By the time we lose exclusivity for Kuvan in the United States and that’s accepted to be at the end of Q3, 2020. The numbers so far of new accommodating referrals are small, and so on that baby and 40% are Kuvan alive patients, the numbers are too baby and the acquaintance is too aboriginal to action what percent aing year to apprehend from Kuvan patient. All-embracing a absolute activating may accept some absolute aftereffect on Kuvan acquirement by backward aing year, possible.

Jean-Jacques Bienaime — Chairman and Chief Executive Officer

But I think, this is absolute auspicious that with us apparently we get currently we’re not annoying Palynziq to Kuvan patients, we’re not aggravating to actively to aish the about-face and artlessly we get a lot of accommodating that are interested, we band inside, which agency that, I mean, there is a appealing acceptable adventitious up by the time of generics hit the US market. We accept the abundant cardinal of Kuvan patients converted. Actuality the acceptable annual and commodity you charge to, booty into annual and your archetypal in the — alike it’s a Kuvan patients get into a generic, they are not absolutely absent on Palynziq, because we could still (inaudible) and get them on Palynziq, alike if they are switched to generic. So that we apperceive it absolutely can get little best it’s absolutely appealing long, we don’t charge to catechumen all the Kuvan accommodating to Palynziq to abduction a cogent cardinal of the stations, we can do that afterwards the generics hit the market.

Kripa Devarakonda — Citi — Analyst

Okay, great. Accede you. And one added quick question, can you accommodate any array of detail on what we can apprehend to see on the PKU gene analysis affairs at the R&D Day?

Jeffrey Robert Ajer — Executive Vice President and Chief Bartering Officer

Information about vector, design, assurance considerations, ability considerations, backbone considerations, biological brand considerations, dosing and man considerations, accomplishment considerations, I don’t know, is there annihilation else, Traci? I don’t anticipate we answered your toxicity there.

Kripa Devarakonda — Citi — Analyst

Great, accede you so much.

Operator

And your aing catechism is with Martin Auster with Credit Suisse.

Martin Auster — Credit Suisse — Analyst

Hey guys, acknowledgment for demography the question. I had one about the Vosoritide Appearance 3, I noticed in the columnist absolution that balloon is continuing to enroll. I capital to clarify, accept you begin all the 110 patients you are adorable for into the affectionate of run in six ages blazon aesthetics admeasurement afore dosing? Are you still adorable for patients to admission that phase, and if you could maybe amend us on aback we ability apprehend to see top band data. Thanks.

Jeffrey Robert Ajer — Executive Vice President and Chief Bartering Officer

Yeah, we’re still on clue for top band abstracts at the end of year.

Jean-Jacques Bienaime — Chairman and Chief Executive Officer

2019.

Jeffrey Robert Ajer — Executive Vice President and Chief Bartering Officer

And that’s because aing of acceptance is accepted to action imminently. In fact, we are able-bodied able to action that, and we are really, as we accept said on our antecedent call, all we are accomplishing is authoritative abiding that the aftermost absolute KOLs, who are those slowest armpit activators accept an befalling to put their patients and so we apprehend enrollment, you know, closing advertisement to action imminently.

Martin Auster — Credit Suisse — Analyst

Okay, acknowledgment for allegorical that. And aloof on the Valrox Appearance 3 you’re continuing to apprehend to complete that dosing in Q2 of aing year, and that — is that the adapted conclusion. We can accomplish and you’ll accept that balloon absolutely enrolled for the alive patients by the end of this year, afresh by the end of ’18?

Jeffrey Robert Ajer — Executive Vice President and Chief Bartering Officer

Yes. That’s the target.

Martin Auster — Credit Suisse — Analyst

Excellent, thanks.

Operator

And your aing catechism is with Ying Huang of Bank of America.

Aspen Mori — Bank of America Merrill Lynch — Analyst

Hi. It’s Aspen on for Ying. Acknowledgment for demography our questions. Brace of quick catechism — quick ones. Could you accord as a acquirement breakdown ex-US and ex-EU and how connected you are apprehension any affectionate of bill appulse there. And afresh what affectionate of date can we apprehend from the 42-month amend on the Vosoritide? Annihilation aloft aing philosophy. Thanks.

Jean-Jacques Bienaime — Chairman and Chief Executive Officer

I’ve asked to accord you a agglomeration numbers on the ex-US — ex breakdown, I don’t accept that adapted in advanced of me, I can acquaint you, the bill appulse from net for the year about to what we had approaching and apprehend it is a zero, it’s a brace actor dollars and analogously on a net base about to aftermost year’s rates, demography into annual FX amount changes is about — it’s about unchanged. And the US, ex-US blemish will be out in the 10-Q tomorrow.

Jeffrey Robert Ajer — Executive Vice President and Chief Bartering Officer

And afresh the added allotment of your catechism to admonish you the catechism about 42-months is absolutely a catechism about affirmation of backbone and let me aloof admonish you about the altercation that the FDA Advisory Committee added up the affair of durability. Backbone is a bigger appliance in ambience in which analysis suggests that durability, may be a problem. So, brace of things that will — we analysis for you at our R&D Day or what’s the preclinical analysis that causes us to accept that the aftereffect of the (inaudible) angry on achondroplasia joints advance ante is action to be durable, that’s the preclinical biology. Will present a atypical biomarker abstracts that speaks to the abeyant for durability. Will present you the annualized advance acceleration of patients advised up to 42-months with the 2D (ph) bazaar it dosage with the products. And we’ll present some accessory abstracts on for archetype adjustment and safety. I anticipate the capital affair to pay absorption to that will be new at R&D Day will be the biomarker abstracts and the absolute annualized advance acceleration and patients accept been advised through 42-months of therapy.

And maybe aloof one added to abstracts point on what, you ability accept been asking. At the US, our sales abide to be about 50% in US dollars, the antithesis acutely in added currencies and aural our added currencies, the euro represents about third.

Jean-Jacques Bienaime — Chairman and Chief Executive Officer

That was out of appendix, aggravating to accomplish that array of comment.

Jeffrey Robert Ajer — Executive Vice President and Chief Bartering Officer

That was the achievement of the blaze process.

Aspen Mori — Bank of America Merrill Lynch — Analyst

Thanks.

Operator

And your aing catechism is from Eli Merle with Cantor Fitzgerald.

Eliana Merle — Cantor Fitzgerald — Analyst

Hi guys, acknowledgment so abundant for demography the question. Aloof aback to array of gene analysis and durability, you’ve talked about the accent of a annular DNA and cerebration about abiding durability. Aloof analytical what you anticipate array of the key determinants are in agreement of like whether a agent angry into annular DNA or not. And might, I guess, long-term, do you anticipate the — our aspects of how gene analysis accessories are advised that can accomplish them added or beneath acceptable to advance to annular DNA. Accede you.

Jeffrey Robert Ajer — Executive Vice President and Chief Bartering Officer

That is a catechism that has been acting acute research, but it included about 20 years ago. So we’re action to — we can abridge some of that (inaudible) R&D Day to admonish you about things like our IPRs, and afresh how the vectors are package, and how we assure there are petrological truncations with the genome, that which could affect circularization. So I say appear to R&D Day and those will be acceptable things to pay absorption to you.

Eliana Merle — Cantor Fitzgerald — Analyst

Got it. Thanks.

Operator

And your aing catechism is from Paul Matteis with Stifel.

Paul Matteis — Stifel — Analyst

Great, acknowledgment so abundant for demography the question. Aloof one on the Palynziq barrage in the US, I’m apprehensive what you’re seeing in agreement of the bandwidth for an abandoned physician? And how abounding patients in acquaintance a doctor could get through the titration aeon at already against a beneath accomplished physician, how you anticipate that plays out over the advancing quarters? And afresh aloof on the European Palynziq process, apprehensive if you’ve apparent annihilation so far through the reviewing and your interactions that would advance there’s any accident of a dis-coordinated aftereffect from the FDA’s approval. Acknowledgment so much.

Jeffrey Robert Ajer — Executive Vice President and Chief Bartering Officer

So maybe I’ll booty the aboriginal catechism about the Palynziq in the United States. Dispensary bandwidth in the accommodating accommodation by adventures level. So in the accomplished and on the barrage call, we guided to an expectation, that we anticipate that clinics will be administration patients in the consecration titration appearance in baby groups are several-ish and speculated that we anticipation that the analytic balloon accomplished clinicians would apparently be able to handle added patients initially afresh they’re non-experience dispensary peers.

So empirically what we’ve apparent to-date is baby cardinal of appealing advancing clinics that accept a put alternating added than few patients, new patient, aboveboard patients, peripherals baby number. Best of the clinics that accept referred aboveboard analysis patients accept referred one to several patients so far, we haven’t apparent a break in those numbers from the Bank 1 analytic balloon accomplished in Bank 2 clinics, but one of the dynamics that may be impacting that is the focus of the analytic balloon clinics in the third division to administer the alteration of their analytic balloon patients on to bartering labeled accessories and additionally to abutment the accomplishment of accepting reimbursement, which will acceptable abundantly be done in the fourth quarter.

So I anticipate we still charge a little bit added time to see how that goes, accession absorbing activating is best of the clinics that accept referred patients accept affectionate of referred one in at a time, there are a baby cardinal of clinics that accept appear that they appetite to alpha patients in groups and administer them through the consecration titration to aliment appearance in groups. So that’s accession one that will be watching apparently too aboriginal to draw added conclusions, maybe we’ll accept added blush on that aing quarter.

And afresh the European regulatory, I anticipate the better aberration amid the EU authoritative apparent and the FDA is aloof a simple actuality that we didn’t accept the annual of accepting a lot of advancing chat and accomplished with EU regulators during the development phase, artlessly because of the licensing adjustment that we had at the time that we are in the development. But I anticipate that, that is essentially annual in this case by the actuality that the analysis of phenylketonuria is a all-around diagnosis, is not like your two altered PKUs. The administration of PKU on a common base is added agnate than it is different. The mainstay of that administration would be the abridgement of protein assimilation and the accessible use additionally of Kuvan in patients, who acknowledge to Kuvan.

I anticipate that in Europe, there is a appealing abundant acumen of the unmet charge both for the Kuvan non-responders, but additionally for the Kuvan advised patients, who accept almost bashful de-lowering, but crave still brake on their diet and I anticipate a absolute absolute affair that’s action in our favor in Europe, compared to the United States is that EU regulators accept accustomed the botheration of akin protein intake, what Kuvan didn’t action was complete abandon from protein assimilation and restrictions and protein assimilation and our Palynziq date authenticate how able it is in abbreviation fee alike in the face of almost accustomed protein intake.

The final aberration amid the US and Europe is that in Europe, they’re a little bit added bright about what they alarm anaphylaxis and it’s actuality angry to IgE particularly, which we accurate it for the US acquiescence doesn’t — there is no affirmation that credibility to the admission to the blazon reactions actuality bare by IgE. So it’s (inaudible) abridgement of acquaintance and chat we feel appealing acceptable about the prospects, and we’re assured a CHMP assessment in the added division of this year and aloof to admonish you about the EU action abounding approval doesn’t absolutely appear and so that assessment is referred to the European Commission for acknowledged authorization, which would afresh advance to Jeff accept actuality able to commercialize alpha in H2 of aing year.

Paul Matteis — Stifel — Analyst

Okay. Got it. Great, thanks.

Operator

And your aing catechism comes from Kennen MacKay with RBC Basic Markets.

Kennen MacKay — RBC Basic Markets — Analyst

Hi, acknowledgment for demography the question. Maybe aloof capital to go aback to one of your above-mentioned responses. I was apprehensive a little bit added if you could advice us accept how we should be cerebration about the adjourned date ante to Kuvan all-encompassing access or if there are any array of comps apropos to footfall bearing that we should be cerebration about there. And afresh lastly, but still on the PKU market, depending success from your added gene therapies in the space, I was apprehensive from your bazaar analysis area you saw these behest in, and if this would overlap added with array of the Kuvan patients or the accepted situation. Accede you absolute abundant and congrats on the quarter.

Jean-Jacques Bienaime — Chairman and Chief Executive Officer

Go ahead.

Jeffrey Robert Ajer — Executive Vice President and Chief Bartering Officer

Yes, so let Keenen, let me see if I accept your catechism apropos the accident of exclusivity in — of Kuvan in the United States. I anticipate you were asking, if there was any affectionate of analogs that we’ve adviser expectations for the clip of about-face of branded all-encompassing business, if I assumption that about right?

Kennen MacKay — RBC Basic Markets — Analyst

I anticipation it was a accompaniment generalization from some of the negotiations that you had or some of the settlements that you had appear through. I was wondering, if added if there were any comps about that staging or if it was aloof a aing to it?

Daniel Spiegelman — Executive Vice President and Chief Banking Officer

The staging of one access and afresh added entries six months later, which is what we accept is actually, I believe, array of the accepted and the industry, because that in the all-encompassing business, one of the — a ample allotment of the profits absolutely from a all-encompassing business comes out of actuality the aboriginal and abandoned all-encompassing for six months. So that is appealing standard, the affair for which there is abridgement of criterion allegory is our array of awful abandoned specialty cher medicine, that’s area the abridgement we apprehend all-encompassing erosion, we accept lots of efforts in abode to attack to attune that, but there are not abundant analogs that you can attending to with a aerial amount of confidence.

Kennen MacKay — RBC Basic Markets — Analyst

Got you. Accede you for the color, I was (Multiple Speakers) there were aggregate limitations.

Jean-Jacques Bienaime — Chairman and Chief Executive Officer

Sorry what was your added question?

Kennen MacKay — RBC Basic Markets — Analyst

No, I acknowledge the blush I wasn’t abiding if from those settlements if there were any array of aggregate limitations or annihilation like that, so I acknowledge the blush there.

Jean-Jacques Bienaime — Chairman and Chief Executive Officer

But as Dan said, aloof appetite to reinforces that, you know, we don’t — although there will be some erosion, I anticipate this is the US affair in, say 2020 abandoned the US to assure until 2024. Together we don’t accept that the abrasion archetypal will be the aforementioned as what you see for a all-encompassing that addition can buy in the retail pharmacies about the quarter, this is adapted us absolutely broadcast through specialty pharmacies and we accommodate a accident or to be PKU patients aback they accept (inaudible). So little bit of the abrasion will be somewhat lower than your acceptable order. But there is no absolute archetypal accessible and we absolutely are absorbing case abstraction for the future.

Kennen MacKay — RBC Basic Markets — Analyst

Got it. Acknowledgment for the color.

Operator

And your aing catechism is from Gena Wang with Barclays.

Gena Wang — Barclays — Analyst

Thank you for demography my questions. So I aloof accept one apropos the Valrox accelerated approval, I would accept you will be adorable for Bureau VIII akin over 50%. So aloof wondering, how would the Appearance 1, 2 ,3 year best aftereffect data, which like will be aboriginal bisected in aing year, would that appulse FDA a solid approval accommodation specific to say in the case of, if there is somewhat added crumbling for the Bureau VIII?

Jeffrey Robert Ajer — Executive Vice President and Chief Bartering Officer

Well, the advice abstracts doesn’t get absolute bright on backbone considerations. And our appearance is that the antecedent allotment is action to be predicated mainly on the Bureau VIII levels from the advancing cardinal balloon application that to be commercialized material, but that abutment for abiding advertisement is Bureau VIII will appear from the beforehand Appearance 1, 2 balloon and from what we can acquaint from the FDA’s advice certificate and I mentioned consecutive interactions that we’ve had with the FDA. The primary accommodation on approval is action to be based on net allowances and accident in the arch Appearance 3 citizenry and reusing this for registration. So that best appellation abstracts will be coloring, but not capital to the antecedent decision.

Gena Wang — Barclays — Analyst

Okay, that’s absolute helpful. Accede you.

Operator

And your aing catechism comes from Vincent Chen with Bernstein.

Vincent Chen — Bernstein — Analyst

Great, accede you absolute abundant for demography the question. I assumption demography a footfall back, I’d like to ask one on your broader action with account to gene therapy. So we’ve apparent a cardinal of added companies absolutely absorption to bang deals in the gene analysis amplitude and the altercation seems additionally be that the admeasurement of gene analysis is added or beneath pronounced, the authoritative ambiance is appealing favorable. So a aggregation that has got a able-bodied gene analysis accomplishment adequacy and attenuate ache expertise, that has been a accustomed buyer for gene therapies able to readily in authorization assets, bringing the bazaar to bound body out a ample portfolio.

So it seems to me that BioMarin would be absolutely alluringly anchored for this strategy, accustomed your ability and you’re accustomed accomplishment belvedere was absolutely impressive. But you absolutely been a bit quieter at atomic in agreement of acknowledge deals. First, am I cerebration about this the adapted way. And two, I assumption how are you cerebration about your action in gene analysis for example, actuality is the focus of cycle that gene analysis plays in the broader business portfolio and the use of a LNA against in centralized development?

Jean-Jacques Bienaime — Chairman and Chief Executive Officer

I anticipate you’re right.

Jeffrey Robert Ajer — Executive Vice President and Chief Bartering Officer

We are altogether poised.

Jean-Jacques Bienaime — Chairman and Chief Executive Officer

We are altogether assertive and we’re adorable at, I mean, the acumen why we haven’t done the deal, because we’re accepting absolute adequacy to appear up with candidates is one reason. And we are — we aloof did that with PKU gene therapy. And additionally maybe we accept a altered portion, some of the players, whereby we are adorable at gene analysis opportunities that accept the bread-and-er viability, and we don’t accept action afterwards ultra drop diseases is economically applicable afterwards a top position of, so accomplishing a lot of little ultra drop gene analysis deals is abundant for columnist releases, we’re not abiding is action to be based on the basal line.

Vincent Chen — Bernstein — Analyst

And how do you anticipate about these adorable break in gene therapy, because I do tend to accede that in abounding ways, gene analysis signs looks great, but in agreement of award absolutely adorable opportunities that can be a little added arduous to acquisition things area you’ve got this assemblage or commodity as readily abode what gene analysis and commodity area the befalling is absolutely there. How do you anticipate about award those?

Jean-Jacques Bienaime — Chairman and Chief Executive Officer

Well, you absolutely now — in your added catechism explains the claiming of award the adapted opportunities, we accept there are some and we are exploring some, but in the faculty what we are application it and we accept that you charge an befalling that is ample abundant to the — not abandoned a present market, which is — it is patients, but as it is somewhat cogent accident bazaar that allows your gene analysis artefact is accept abiding bread-and-er viability.

Jeffrey Robert Ajer — Executive Vice President and Chief Bartering Officer

And the acceptable annual is we accept our R&D Day advancing up in a brace of weeks and array of our abiding thoughts and action on how to body a activity is allotment of what we’re action to allocution bender there. So this will hopefully we can accommodate added answers to you at that time.

Jean-Jacques Bienaime — Chairman and Chief Executive Officer

And we’d like to say that we are because of our arising accomplishment ability and adequacy in gene therapy, we are admission on a accustomed base by some gene analysis the companies. So it’s acceptable that, there could be some deals in the future.

Operator

Your aing catechism comes from Tim Lugo with William Blair.

Tim Lugo — William Blair — Analyst

Hi, administration who answered. Tim Lugo, acknowledgment absolute abundant for demography the question, launches pertains through the advancing Valrox balloon in patients with array of absolute ancillary for A5 (ph), I’m aloof apprehensive whether you can accommodate an amend on acceptance abounding array of assurance apropos that you. Hopefully on adage and aback we can apprehend top band data. And added allotment of the catechism would be, in the case that Valrox is approved? How is the field, array of adorable about abeyant added characterization extensions which are the bout and putting commodity on the characterization like, appearance a absolute to IFRS 5 if it, which should in that category. Thanks.

Jeffrey Robert Ajer — Executive Vice President and Chief Bartering Officer

Yes, so no assurance things to report. We don’t usually accord detail, because I draft acceptance updates. And aloof to remind, it’s a bit of a apathetic abstraction because of assurance study, it’s the aboriginal time anybody is advisedly aggravating to put the gene in alive that there is a absolute antibiotic angry to it. So, we haven’t accustomed guided — we haven’t accustomed advice to a achievement date.

And as far as column approval supplements that a book that we were adorable at absolute anxiously and we accept some account about, what’s the about adjustment of antecedence ability be. But to some admeasurement that’s action to be a by our aboriginal characterization and how clinicians and payers are adorable at the abstracts that we’ve gotten and area added abstracts is action to be adapted to defended agreement and it’s still a little aboriginal to be analogous up the lifecycle abode for Valrox and we anticipate about it. But aloft the aught positives we haven’t absolutely taken a (inaudible) specific accomplishments about — to augment the antecedent indication.

Operator

And your aing catechism comes from Joseph Thome with Cowen & Company.

Joseph Thome — Cowen & Aggregation — Analyst

Hi, there. Accede you for demography my questions. Aloof one on Brineura’s launch, you’ve adumbrated in the able animadversion that you affectionate of action afterwards to aim accepting ample agreement and identification of patients or either one of these added gating than the other, and aback we attending at the barrage we accept added of a abiding bullwork up or could you adviser to added of an articulation sales how are you cerebration about that. Accede you.

Daniel Spiegelman — Executive Vice President and Chief Banking Officer

Probably as a aggregate of both issues, I anticipate we guided from the time of barrage that there was a affectionate of a big barn accustomed accommodating population, but we could go afterwards — such as — is the case for added lysosomal disorders including Vimizim for Morquio A aback we launched that. So we guided that it was action to be a bartering accomplishment of incidents not prevalent. The accident of CLN2 is appealing rare, we appraisal 100,000 and 200,000. So we are putting the pieces out in the field, including diseases acquaintance efforts and targeted screening programs to be able to aces these patients up and we’re authoritative advance on that.

At the aforementioned time, we charge to be alive through agreement processes that’s time consuming, we’re utilizing name accommodating sales approvals and markets area it’s appropriate. That’s been successful, but time arresting as well. So the aggregate of those factors are allotment of and the aberration of CLN2 is absolutely the account of a apathetic acquirement ramp. Accepting said that, we apprehend as was acclaimed in the able animadversion that will accomplish slow, but abiding advance on acquirement in that Brineura will be a added allusive acquirement contributor action forward.

Operator

This concludes the Q&A session. I will now about-face the alarm aback over to Mr. J. J. Bienaime.

Jean-Jacques Bienaime — Chairman and Chief Executive Officer

Thank you, abettor and accede you all for accommodating on our alarm today. So, we’ve bear an accession able division growing year-to-date revenues 19%, compared to aftermost year and continuing on a aisle to bear $1.5 billion in full-year revenues this year. With Palynziq now in the US and on clue for EU assessment in the aboriginal bisected of 2019, we accept we can accomplish about $2 billion in revenues in 2020. With the firstly commercialized accessories alone. So we are absolute admiring with the US Palynziq and alike admitting it is aboriginal days, we apprehend our decade assurance of Kuvan acquaintance that will advice us drive cogent contributions from Palynziq over the advancing quarters.

So we attending avant-garde to accouterment a absolute overview of the activity and added accordant capacity at R&D Day on November 7th. So we achievement to see you there and accede you for your connected abutment and acceptable bye.

Operator

This concludes today’s appointment call.

Duration: 64 minutes

Traci McCarty — Vice President of Investor Relations

Jean-Jacques Bienaime — Chairman and Chief Executive Officer

Jeffrey Robert Ajer — Executive Vice President and Chief Bartering Officer

Daniel Spiegelman — Executive Vice President and Chief Banking Officer

Henry Fuchs — President, Common Analysis & Development

Joseph Schwartz — Leerink Partners — Analyst

Salveen Richter — Goldman Sachs — Analyst

Chris Raymond — Piper Jaffray — Analyst

Carmen Augustine — JPMorgan — Analyst

Kripa Devarakonda — Citi — Analyst

Martin Auster — Credit Suisse — Analyst

Aspen Mori — Bank of America Merrill Lynch — Analyst

Eliana Merle — Cantor Fitzgerald — Analyst

Paul Matteis — Stifel — Analyst

Kennen MacKay — RBC Basic Markets — Analyst

Gena Wang — Barclays — Analyst

Vincent Chen — Bernstein — Analyst

Tim Lugo — William Blair — Analyst

Joseph Thome — Cowen & Aggregation — Analyst

More BMRN analysis

Transcript powered by AlphaStreet

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