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MONT-SAINT-GUIBERT, Belgium, Oct. 04, 2018 (GLOBE NEWSWIRE) — Celyad (Euronext Brussels and Paris, and NASDAQ: CYAD), a clinical-stage biopharmaceutical aggregation focused on the development of specialized CAR-T cell-based therapies, today appear an absolute acceding with Horizon Analysis Group plc (LSE: HZD), for the use of its shRNA technology to accomplish Celyad’s added non-gene-edited allogeneic platform.

Celyad afresh appear its first-in-class non-gene edited allogeneic CAR-T candidate, CYAD-101 a non-gene-edited allogeneic NKG2D-based CAR application the TIM (TCR Inhibiting Molecule).  As a aftereffect of the acceding with Horizon Discovery, Celyad now additionally has admission to a atypical shRNA-based platform.

Data from preclinical studies demonstrating the versatility of the shRNA belvedere in the allogeneic setting, will be presented at the accessible 2018 Society for Immunotherapy of Blight (SITC) Annual Meeting in Washington, D.C., November 7th – 11th. These able preclinical abstracts will pave the way for the aing accomplish in the development of Celyad’s differentiated non-gene edited allogeneic access to CAR-T corpuscle therapy.  

“We are aflame to accept the befalling to advantage Horizon’s shRNA belvedere to added beforehand our beat access to non-gene edited allogeneic CAR-T cells,” said Dr. Christian Homsy, CEO of Celyad. “Celyad is committed to rapidly advancing its allogeneic affairs based on awful able preclinical abstracts which will be presented at SITC. These abstracts accommodate affidavit of abstraction for our shRNA based non-gene-edited allogeneic approach. In accession to absolute able preclinical data, our allogeneic access is additionally adequate by Celyad’s able apparent acreage in the U.S., which broadly covers the use of allogeneic CAR-T application beef that are TCR inhibited or suppressed by any means.”

Jon Moore, CSO of Horizon Analysis added: “The aerial achievement shRNA technology accountant by Celyad is the aforementioned as that deployed in our ambit of SMARTvector articles and is brash to bear able ambition beating bottomward with aerial specificity. Horizon’s accord with Celyad is brash to let Celyad accretion a awful able band-aid for its needs. Horizon sees its shRNA technology as a austere battling to gene alteration approaches for carrying added achievement to ameliorative corpuscle products. We see astronomic affiance in corpuscle therapies and are committed to beforehand and accumulation avant-garde technologies that acquiesce our ally to accompany transformative corpuscle therapies to the dispensary and fulfil unmet analytic needs.” 

About Celyad

Celyad is a clinical-stage biopharmaceutical aggregation focused on the development of specialized CAR-T cell-based therapies. Celyad utilizes its adeptness in corpuscle engineering to ambition cancer. Celyad’s CAR-T corpuscle belvedere has the abeyant to amusement a ample ambit of solid and hematologic tumors. Its beforehand oncology candidate, CYAD-01 (CAR-T NKG2D), is currently evaluated in a Phase I dosage accretion analytic balloon to appraise the assurance and analytic action of assorted administrations of autologous CYAD-01 beef in seven adverse cancers including bristles solid tumors (colorectal, ovarian, bladder, triple-negative and pancreatic cancers) and two hematological tumors (acute myeloid leukemia and assorted myeloma). The assurance and analytic action of the CYAD-01 analysis accordingly administered with standard-of-care treatments or preconditioning chemotherapy is additionally adjourned in a abounding analytic development affairs focused on astute myeloid leukemia and colorectal cancer. Celyad was founded in 2007 and is based in Mont-Saint-Guibert, Belgium, and New York, NY. Celyad’s accustomed shares are listed on the Euronext Brussels and Euronext Paris exchanges, and its American Depository Shares are listed on the NASDAQ Global Market, all beneath the ticker attribute CYAD.

For added information, amuse contact:

About Horizon Analysis Group plc www.horizondiscovery.com

Horizon Analysis Group plc (LSE: HZD) (“Horizon”) is a apple baton in gene alteration and gene accentuation technologies. Horizon designs and engineers beef application its translational genomics platform, a awful absolute and adjustable apartment of DNA alteration accoutrement (rAAV, ZFN, CRISPR and Transposon) and, afterward the accretion of Dharmacon, Inc., its anatomic genomics belvedere absolute gene altercation (RNAi) and gene announcement (cDNA, ORF) tools, for analysis and analytic applications that beforehand animal health. Horizon’s platforms and capabilities accredit advisers to adapt about any gene or attune its action in animal or beastly corpuscle lines.

Horizon offers an all-encompassing ambit of archive articles and accompanying analysis casework to abutment a greater compassionate of the action of genes beyond all breed and the abiogenetic drivers of animal ache and the development of alone molecular, corpuscle and gene therapies. These accept been adopted by over 10,000 academic, biologic discovery, biologic accomplishment and analytic affection barter about the globe, as able-bodied as in the Company’s own R&D pipeline.

Horizon is headquartered in Cambridge, UK, and is listed on the London Stock Exchange’s AIM bazaar beneath the ticker “HZD.”

For added advice from Horizon Analysis Group plc, amuse contact:

Zyme Communications (Trade and Regional Media)Katie OdgaardTel: 44 (0)7787 502 947Email: [email protected]

Horizon Analysis Group plcTerry Pizzie, Chief Executive OfficerRichard Vellacott, Chief Banking OfficerTel: 44 (0) 1223 655 580

Forward-looking statementsThis absolution may accommodate advanced statements, including statements apropos the assurance and adeptness of CYAD-01 and the new mAb accomplishment adjustment acclimated to accomplish this biologic artefact candidate; statements apropos the advancing and planned analytic development of CYAD-01, including the timing of abstracts readouts and presentations; the analytic and bartering abeyant of CYAD-01 and the capability of Celyad’s banking resources; Celyad’s banking condition, after-effects of operation and business outlook; and Celyad’s accepted banknote burn. Advanced statements may absorb accepted and alien risks, uncertainties and added factors which adeptness account absolute results, banking action and liquidity, achievement or achievements of Celyad, or industry results, to alter materially from those bidding or adumbrated by such advanced statements. In accurate it should be acclaimed that the acting abstracts abbreviated aloft are basic in nature. There is bound abstracts apropos assurance and analytic action afterward analysis with the CYAD-01 biologic artefact candidate. These after-effects may not be again or empiric in advancing or approaching studies involving the CYAD-01 biologic artefact candidate. These advanced statements are added able by important factors and risks, which could account absolute after-effects to alter materially from those in the advanced statements, including statements about: the initiation, timing, beforehand and after-effects of our preclinical studies and analytic trials, and our analysis and development programs; our adeptness to beforehand biologic artefact candidates into, and auspiciously complete, analytic trials; our adeptness to auspiciously accomplish biologic artefact for our analytic trials, including with our new mAb accomplishment action and with account to accomplishment biologic artefact with the adapted cardinal of T beef beneath our analytic balloon protocols; our assurance on the success of our biologic artefact candidates, including our assurance on the authoritative approval of CYAD-01 in the United States and Europe and consecutive bartering success of CYAD-01, both of which may never occur; the timing or likelihood of authoritative filings and approvals; our adeptness to beforehand sales and business capabilities; the commercialization of our biologic artefact candidates, if approved; the appraisement and agreement of our biologic artefact candidates, if approved; the accomplishing of our business model, cardinal affairs for our business, biologic artefact candidates and technology; the ambit of aegis we are able to authorize and advance for bookish acreage rights accoutrement our biologic artefact candidates and technology;  our adeptness to accomplish our business after infringing, misappropriating or contrarily actionable the bookish acreage rights and proprietary technology of third parties; amount associated with administration or arresting bookish acreage infringement, confiscation or violation; artefact liability; and added claims;  authoritative development in the United States, the European Union, and added jurisdictions; estimates of our expenses, approaching revenues, basic requirements and our needs for added financing;  the abeyant allowances of cardinal accord agreements and our adeptness to access into cardinal arrangements; our adeptness to advance and authorize collaborations or access added admission funding;  the amount and amount of bazaar accepting of our biologic artefact candidates, if approved; our banking performance;  developments apropos to our competitors and our industry, including aggressive therapies and statements apropos approaching revenue, hiring plans, expenses, basic expenditures, basic requirements and allotment performance. A added account and description of these risks, uncertainties and added risks can be begin in Celyad’s U.S. Securities and Exchange Commission (SEC) filings and reports, including in its Annual Report on Form 20-F filed with the SEC on April 6, 2018 and consecutive filings and letters by Celyad. Given these uncertainties, the clairvoyant is brash not to abode any disproportionate assurance on such advanced statements. These advanced statements allege alone as of the date of advertisement of this certificate and Celyad’s absolute after-effects may alter materially from those bidding or adumbrated by these advanced statements. Celyad especially disclaims any obligation to amend any such advanced statements in this certificate to reflect any change in its expectations with attention thereto or any change in events, altitude or affairs on which any such account is based, unless appropriate by law or regulation. 

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