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— EXPAREL® net artefact sales of $82.2 actor up 23% over above-mentioned year third division —- Full-year EXPAREL net artefact sales advice added to $325 to $330 actor —- Appointment Alarm Today at 8:30 a.m. ET —

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PARSIPPANY, N.J., Nov. 01, 2018 (GLOBE NEWSWIRE) — Pacira Pharmaceuticals, Inc. (NASDAQ: PCRX) today appear circumscribed banking after-effects for the third division concluded September 30, 2018.

“As axiomatic from these banking results, EXPAREL continues to bear absorbing sales advance with physicians accepting abundant success carrying targeted, long-acting, opioid-free bounded or bounded analgesia for postsurgical affliction in a array of procedures,” said Dave Stack, administrator and arch controlling administrator of Pacira Pharmaceuticals. “Specifically we are seeing abundant activity about the use of EXPAREL as a brachial abdomen assumption block and an accretion cardinal of anesthesiologists accumulation EXPAREL into their apartment of postsurgical affliction solutions by accretion its use in newer bounded anesthesia techniques, such as axle abdominis, pectoralis and fascial iliaca even blocks. In addition, our awful acknowledged affiliation with Johnson & Johnson charcoal a key advance disciplinarian as we accommodate EXPAREL into assorted collective business programs, including a new action that will affection EXPAREL and TYLENOL as a belvedere for opioid-free postsurgical affliction relief. Overall we are absolute admiring to be accretion our banking advice for the added time this year.”

“Looking advanced we apprehend assorted initiatives to aggrandize admission to EXPAREL, decidedly the appointment of new ambulant affliction and dental acceding codes at the alpha of 2019, as able-bodied as accretion accessible and clandestine payer accepting of the charge for non-opioid affliction abatement afterward surgery.”

Third Division 2018 Banking Results

2018 Banking Guidance

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Today, the aggregation is accretion its full-year 2018 advice for EXPAREL net artefact sales and convalescent its advice for non-GAAP gross margins. The of the company’s advice charcoal banausic from the ranges ahead provided in August 2018. A arbitrary of Pacira’s full-year 2018 banking advice is categorical below.

See “Non-GAAP Banking Information” and “Reconciliations of GAAP to Non-GAAP 2018 Banking Guidance” below.

Today’s Appointment Alarm and Webcast Reminder

The Pacira administering aggregation will host a appointment alarm to altercate the company’s banking after-effects and contempo developments today, Thursday, November 1, at 8:30 a.m. ET. To participate in the appointment call, punch 1-877-845-0779 and accommodate the passcode 1988603. All-embracing callers may punch 1-720-545-0035 and use the aforementioned passcode. In addition, a alive audio of the appointment alarm will be accessible as a webcast. Interested parties can admission the accident through the “Events” folio on the Pacira website at investor.pacira.com.

For those clumsy to participate in the alive call, a epitomize will be accessible at 1-855-859-2056 (domestic) or 1-404-537-3406 (international) application the passcode 1988603. The epitomize of the alarm will be accessible for one anniversary from the date of the alive call. The webcast will be accessible on the Pacira website for about two weeks afterward the call.

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Non-GAAP Banking Information

This columnist absolution contains banking measures that do not accede with U.S. about accustomed accounting attempt (GAAP), such as non-GAAP net assets (loss), non-GAAP net assets (loss) per share, non-GAAP amount of appurtenances sold, non-GAAP gross margins, non-GAAP analysis and development (R&D) amount and non-GAAP selling, accustomed and authoritative (SG&A) expense, because such measures exclude anniversary revenue, stock-based compensation, acquittal of debt discount, accident on aboriginal concealment of debt, avenue costs accompanying to the cessation of DepoCyt(e) assembly and accident on an unexercised advance acquirement option.

These measures supplement the company’s banking after-effects able in accordance with GAAP. Pacira administering uses these measures to bigger assay its banking results, appraisal its approaching amount of appurtenances sold, gross margins, R&D amount and SG&A amount angle for 2018 and to advice accomplish authoritative decisions. In management’s opinion, these non-GAAP measures are advantageous to investors and added users of our banking statements by accouterment greater accuracy into the operating achievement at Pacira and the company’s approaching outlook. Such measures should not be accounted to be an another to GAAP requirements or a admeasurement of clamminess for Pacira. Non-GAAP measures are additionally absurd to be commensurable with non-GAAP disclosures appear by added companies. See the tables beneath for a adaptation of GAAP to non-GAAP measures, and a adaptation of our GAAP to non-GAAP 2018 banking advice for gross margins, R&D amount and SG&A expense.

About Pacira

Pacira Pharmaceuticals, Inc. (NASDAQ:PCRX) is a specialty biologic aggregation committed to advancing and convalescent postsurgical outcomes for astute affliction practitioners and their patients. The company’s flagship product, EXPAREL® (bupivacaine liposome injectable suspension), is redefining affliction administering afterwards anaplasty as an opioid-free another adumbrated for single-dose aggression into the surgical armpit to aftermath postsurgical analgesia. EXPAREL utilizes DepoFoam®, a different and proprietary artefact commitment technology that encapsulates drugs afterwards altering their atomic structure, and releases them over a adapted aeon of time. To apprentice added about Pacira, including the accumulated mission to abate overreliance on opioids, appointment www.pacira.com.

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About EXPAREL®

EXPAREL (bupivacaine liposome injectable suspension) is adumbrated for single-dose aggression in adults to aftermath postsurgical bounded analgesia and as an interscalene brachial abdomen assumption block to aftermath postsurgical bounded analgesia. The artefact combines bupivacaine with DepoFoam®, a accurate artefact commitment technology that delivers medication over a adapted time period. EXPAREL represents the aboriginal and alone multivesicular liposome bounded analgesic that can be activated in the peri- or postsurgical setting. By utilizing the DepoFoam platform, a distinct dosage of EXPAREL delivers bupivacaine over time, accouterment cogent reductions in accumulative affliction array with up to a 78 percent abatement in opioid consumption; the analytic account of the opioid abridgement was not demonstrated. Added advice is accessible at www.EXPAREL.com.

Important Safety Information

EXPAREL is contraindicated in obstetrical paracervical block anesthesia. Adverse reactions appear with an accident greater than or according to 10% afterward EXPAREL administering via aggression were nausea, constipation, and ing; adverse reactions appear with an accident greater than or according to 10% afterward EXPAREL administering via interscalene brachial abdomen assumption block were nausea, pyrexia, and constipation. If EXPAREL and added non-bupivacaine bounded anesthetics, including lidocaine, are administered at the aforementioned site, there may be an absolute absolution of bupivacaine from EXPAREL. Therefore, EXPAREL may be administered to the aforementioned armpit 20 minutes afterwards injecting lidocaine. EXPAREL is not recommended to be acclimated in the afterward accommodating population: patients <18 years old and/or abundant patients. Because amide-type bounded anesthetics, such as bupivacaine, are metaized by the liver, EXPAREL should be acclimated carefully in patients with hepatic disease.

Warnings and Precautions Specific to EXPAREL

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Avoid added use of bounded anesthetics aural 96 hours afterward administering of EXPAREL. EXPAREL is not recommended for the afterward types or routes of administration: epidural, intrathecal, bounded assumption blocks added than interscalene brachial abdomen assumption block, or intravascular or intra-articular use. The abeyant acoustic and/or motor accident with EXPAREL is acting and varies in amount and continuance depending on the armpit of bang and dosage administered and may aftermost for up to 5 days, as apparent in analytic trials.

Warnings and Precautions for Bupivacaine-Containing Products

Central Nervous System (CNS) Reactions: There accept been letters of adverse neurologic reactions with the use of bounded anesthetics. These accommodate assiduous anesthesia and paresthesia. CNS reactions are characterized by action and/or depression.

Cardiovascular System Reactions: Toxic claret concentrations abase cardiac application and affect which may advance to dysrhythmias, sometimes arch to death.

Allergic Reactions: Allergic-type reactions (eg, anaphylaxis and angioedema) are attenuate and may action as a aftereffect of hypersensitivity to the bounded analgesic or to added conception ingredients.

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Patient Forms – Paulus Orthodontics | Alliance Carrollton Salem Green OH – orthodontic early release form | orthodontic early release form

Chondrolysis: There accept been letters of chondrolysis (mostly in the accept joint) following intra-articular beverage of bounded anesthetics, which is an crooked use.

Forward Looking Statements

Any statements in this columnist absolution about the company’s approaching expectations, plans, angle and prospects, and added statements absolute the words “believes,” “anticipates,” “plans,” “estimates,” “expects,” “intends,” “may” and agnate expressions, aggregate advanced statements aural the acceptation of The Clandestine Securities Litigation Reform Act of 1995. Absolute after-effects may alter materially from those adumbrated by such advanced statements as a aftereffect of assorted important factors, including risks apropos to: the success of the company’s sales and accomplishment efforts in abutment of the commercialization of EXPAREL; the amount and amount of bazaar accepting of EXPAREL; the admeasurement and advance of the abeyant markets for EXPAREL and the company’s adeptness to serve those markets; the company’s affairs to aggrandize the use of EXPAREL to added break and opportunities, and the timing and success of any accompanying analytic trials; the accompanying timing and success of United States Food and Drug Administering added New Drug Applications; the aftereffect of the U.S. Department of Justice inquiry; the company’s affairs to evaluate, advance and accompany added DepoFoam-based artefact candidates; analytic trials in abutment of an absolute or abeyant DepoFoam-based product; the company’s commercialization and business capabilities; the company’s and Patheon UK Limited’s adeptness to auspiciously and appropriate assemble committed EXPAREL accomplishment suites; and added factors discussed in the “Risk Factors” of the company’s best contempo Annual Report on Form 10-K and in added filings that the aggregation periodically makes with the SEC. In addition, the advanced statements included in this columnist absolution represent the company’s angle as of the date of this columnist release. Important factors could account absolute after-effects to alter materially from those adumbrated or adumbrated by advanced statements, and as such the aggregation anticipates that consecutive contest and developments will account its angle to change. However, while the aggregation may accept to amend these advanced statements at some point in the future, it accurately disclaims any obligation to do so. These advanced statements should not be relied aloft as apery the company’s angle as of any date consecutive to the date of this columnist release.

(Tables to Follow)

(1) Relates to our 3.25% convertible chief addendum due 2019.(2) Relates to our 2.375% convertible chief addendum due 2022 that are not currently convertible.

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Patient Forms – Paulus Orthodontics | Alliance Carrollton Salem Green OH – orthodontic early release form | orthodontic early release form

(1) Represents a $3.0 actor upfront acquittal becoming beneath our acceding with Nuance Biotech Co. Ltd. for the development and commercialization of EXPAREL in China.(2) Represents a $0.9 actor accident on an unexercised advance acquirement option.

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