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Basel, October 26, 2018 – Novartis, a baton in immuno-dermatology and rheumatology, appear today that the European Commission (EC) has accustomed a characterization amend for Cosentyx® (secukinumab). Cosentyx is the aboriginal and alone fully-human assay that accurately inhibits interleukin-17A (IL-17A), in psoriatic arthritis (PsA)[1]. The new characterization amend includes dosing adaptability of up to 300 mg based on analytic acknowledgment that will accommodate clinicians with greater best for their patients[1].

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The characterization amend additionally includes 24-week structural abstracts with subcutaneous (sc) regimens demonstrating that Cosentyx inhibits progression of collective accident in PsA[1].

“Cosentyx has apparent that it can apathetic the progression of collective accident inflicted by psoriatic arthritis, which can advance to cogent advancement accident for patients,” said Paul EmeryProfessor of Rheumatology, Arthritis Assay UK and Director Leeds NIHR Biomedical Assay Centre. “The characterization amend allows dosing adaptability up to 300 mg, giving clinicians and patients greater best in how to ambition this accelerating and debilitating condition, based on alone acknowledgment to treatment.”

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This characterization amend is cogent as PsA can advance to cogent advancement accident and irreversible collective accident if sub-optimally-treated[5]. PsA is a chronic, accelerating and irreversible ache arch to pain, fatigue, as able-bodied as action crime and cogent advancement accident due to structural damage[5].

The characterization amend is based on Cosentyx abiding adeptness and constant assurance afterward up-titration to 300 mg in PsA. Cosentyx accurately inhibits IL-17A – a cornerstone cytokine complex in the development of spondyloarthritis and psoriatic disease[1],[6]-[8]. The 24-week structural ache progression abstracts are from FUTURE 5, the better Phase III abstraction for a biologic conducted in PsA to date (996 patients)[2]. In this study, about 90% of patients advised with Cosentyx 300 mg had no radiographic ache progression at 24 weeks[2].

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“Cosentyx is the alone IL-17A inhibitor to authenticate 5-year assurance and adeptness in Phase III studies of PsA and AS. We are reimagining the abundance of patients active with all facets of psoriatic arthritis,” said Eric Hughes, All-around Development Unit Head, Immunology, Hepatology and Dermatology. “This characterization amend added supports prescribing doctors and patients in their assay choice.”

The characterization amend is applicative to all European Union and European Bread-and-er Area countries and is able immediately. To date, Cosentyx has been assigned to added than 160,000 patients worldwide[9].

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About Cosentyx Cosentyx is the aboriginal and alone fully-human biologic that accurately inhibits interleukin-17A (IL-17A), a cornerstone cytokine complex in the deepening and development of psoriasis, ankylosing spondylitis, and PsA[1],[6]-[8]. IL-17A is produced by assorted beef from both the congenital allowed arrangement (which can be triggered by automated stress) and the adaptive allowed system[3]. To date, Cosentyx has been assigned to added than 160,000 patients worldwide[9] and is actuality evaluated in 100 studies, including a absolute head-to-head analytic balloon program[10]-[16].

DisclaimerThis columnist absolution contains advanced statements aural the acceptation of the United States Private Securities Litigation Reform Act of 1995. Advanced statements can about be articular by words such as “potential,” “can,” “will,” “plan,” “expect,” “anticipate,” “look forward,” “believe,” “committed,” “investigational,” “pipeline,” “launch,” or agnate terms, or by accurate or adumbrated discussions apropos abeyant business approvals, new break or labeling for the investigational or accustomed articles declared in this columnist release, or apropos abeyant approaching revenues from such products. You should not abode disproportionate assurance on these statements. Such advanced statements are based on our accepted behavior and expectations apropos approaching events, and are accountable to cogent accepted and alien risks and uncertainties. Should one or added of these risks or uncertainties materialize, or should basal assumptions prove incorrect, absolute after-effects may alter materially from those set alternating in the advanced statements. There can be no agreement that the investigational or accustomed articles declared in this columnist absolution will be submitted or accustomed for auction or for any added break or labeling in any market, or at any accurate time. Nor can there be any agreement that such articles will be commercially acknowledged in the future. In particular, our expectations apropos such articles could be afflicted by, amid added things, the uncertainties inherent in assay and development, including analytic balloon after-effects and added assay of absolute analytic data; authoritative accomplishments or delays or government adjustment generally; all-around trends against bloom affliction amount containment, including government, payor and accepted accessible appraisement and agreement pressures; our adeptness to admission or advance proprietary bookish acreage protection; the accurate prescribing preferences of physicians and patients; accepted political and bread-and-er conditions; safety, affection or accomplishment issues; abeyant or absolute abstracts aegis and abstracts aloofness breaches, or disruptions of our advice technology systems, and added risks and factors referred to in Novartis AG’s accepted Form 20-F on book with the US Securities and Exchange Commission. Novartis is accouterment the advice in this columnist absolution as of this date and does not undertake any obligation to amend any advanced statements independent in this columnist absolution as a aftereffect of new information, approaching contest or otherwise.

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About NovartisNovartis is reimagining anesthetic to advance and extend people’s lives. As a arch all-around medicines company, we use avant-garde science and agenda technologies to actualize transformative treatments in areas of abundant medical need. In our adventure to acquisition new medicines, we consistently rank amid the world’s top companies advance in assay and development. Novartis articles ability about 1 billion bodies globally and we are award avant-garde means to aggrandize admission to our latest treatments. About 125 000 bodies of added than 140 nationalities assignment at Novartis about the world. Acquisition out added at http://www.novartis.com

Novartis is on Twitter. Sign up to chase @Novartis at http://twitter.com/novartisFor Novartis multimedia content, amuse appointment www.novartis.com/news/media-libraryFor questions about the armpit or appropriate registration, amuse acquaintance [email protected]

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References[1]   EMA Cosentyx Summary of Product Characteristics | European Medicines Agency. | European Medicines Agency. [online] Available at: http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/003729/human_med_001832.jsp&mid=WC0b01ac058001d124 [Accessed October 2018].[2]   Mease P et al. Subcutaneous Secukinumab Inhibits Radiographic Progression in Psoriatic Arthritis: Primary After-effects from a Large Randomized, Controlled, Double-Blind Phase 3 Study. Presented as a late-breaker at the 2017 ACR/ARHP Annual Meeting. November 7, 2017.[3]   Schett G et al. Enthesitis: from pathophysiology to treatment. Nat Rev Rheumatol. 2017;1(12):731-741.[4]   Keijsers RR et al. Cellular sources of IL-17 in psoriasis: a archetype shift? Exp Dermatol 2014;23(11):799-803.[5]   Mease P et al. Managing Patients with Psoriatic Disease: The Diagnosis and Pharmacologic Assay of Psoriatic Arthritis in Patients with Psoriasis. Drugs 2014;74:423-41.[6]   Smith JA et al. Review: The Interleukin 23/Interleukin 17 Axis in Spondyloarthritis Pathogenesis: Th17 and Beyond. Arthritis Rheumatol. 2014;66:231-41.[7]   Nestle FO et al. Mechanisms of ache psoriasis. N Eng J Med. 2009;361:496-509.[8]   Girolomoni G et al. Psoriasis: account for targeting interleukin-17. Br J Dermatol. 2012;167:717-24.[9]   Novartis. Abstracts on file.[10] Langley RG et al. Secukinumab in Applique Crawling – After-effects of Two Phase 3 Trials. N Engl J Med 2014;371:326-38.[11] Blauvelt A et al. Secukinumab is above to ustekinumab in allowance bark of capacity with moderate-to-severe applique crawling up to 1 year: After-effects from the CLEAR study. J Am Acad Dermatol. 2017;76(1):60-69.[12] Bagel J et al. Secukinumab is Above to Ustekinumab in Allowance Bark of Patients with Moderate to Severe Applique Psoriasis: CLARITY, a Randomized, Controlled, Phase 3b Trial. Presented as affiche 98 at The Winter Analytic Dermatology Conference – Hawaii. January 13, 2018.[13] Effect of Secukinumab on Radiographic Progression in Ankylosing Spondylitis as compared to GP2017 (Adalimumab Biosimilar) (SURPASS). Available at: https://www.clinicaltrials.gov/ct2/show/NCT03259074. [Accessed October 2018].[14] Adeptness of Secukinumab Compared to Adalimumab in Patients With Psoriatic Arthritis (EXCEED 1). Available at: https://clinicaltrials.gov/ct2/show/NCT02745080. [Accessed October 2018].[15] Comparison of Secukinumab Versus Guselkumab in Allowance Psoriatic Plaques Refractory to Ustekinumab (ARROW). Available at https://clinicaltrials.gov/ct2/show/NCT03553823. [Accessed October 2018].[16] Clinicaltrials.gov. (2018). Search of: secukinumab | Recruiting, Not yet recruiting, Active, not recruiting, Completed, Enrolling by allurement Studies – List After-effects – ClinicalTrials.gov. [online] Available at: https://clinicaltrials.gov/ct2/results?term=secukinumab&Search=Apply&recrs=b&recrs=a&recrs=f&recrs=d&recrs=e&age_v=&gndr=&type=&rslt= [Accessed October. 2018].

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